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Highly Regio‐ and Enantioselective Synthesis of γ,δ‐Unsaturated Amido Esters by Catalytic Hydrogenation of Conjugated Enamides
Author(s) -
Gao Min,
Meng Jingjing,
Lv Hui,
Zhang Xumu
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201410213
Subject(s) - enantioselective synthesis , chemistry , catalysis , asymmetric hydrogenation , conjugated system , organic chemistry , noyori asymmetric hydrogenation , combinatorial chemistry , polymer
An efficient and highly regio‐ and enantioselective catalytic asymmetric hydrogenation of α,γ‐dienamido esters to γ,δ‐unsaturated amido esters has been achieved using Rh/TangPhos as the catalyst. A series of γ,δ‐unsaturated amido acids were furnished in excellent yields with up to 99 % ee . This effective methodology was applied in the asymmetric synthesis of key intermediate of Ramipril, an ACE inhibitor.