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Heteroatom‐embedded Medium‐Sized Cycloalkynes: Concise Synthesis, Structural Analysis, and Reactions
Author(s) -
Ni Runyan,
Mitsuda Naoto,
Kashiwagi Takeru,
Igawa Kazunobu,
Tomooka Katsuhiko
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409910
Subject(s) - moiety , alkyne , cycloaddition , heteroatom , chemistry , reactivity (psychology) , ring (chemistry) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
A variety of medium‐sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.