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Cobalt‐Catalyzed C(sp 2 )H Alkoxylation of Aromatic and Olefinic Carboxamides
Author(s) -
Zhang LinBao,
Hao XinQi,
Zhang ShouKun,
Liu ZhanJiang,
Zheng XinXiang,
Gong JunFang,
Niu JunLong,
Song MaoPing
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409751
Subject(s) - catalysis , chemistry , benzamide , cobalt , medicinal chemistry , aromaticity , organic chemistry , molecule
The cobalt‐catalyzed alkoxylation of C(sp 2 )H bonds in aromatic and olefinic carboxamides has been developed. The reaction proceeded under mild conditions in the presence of Co(OAc) 2 ⋅4H 2 O as the catalyst and tolerates a wide range of both alcohols and benzamide substrates, including even olefinic carboxamides. In addition, this reaction is the first example of the direct alkoxylation of alkenes through CH bond activation.