AgF‐Mediated Fluorinative Cross‐Coupling of Two Olefins: Facile Access to α‐CF 3 Alkenes and β‐CF 3 Ketones

A AgF‐mediated fluorination with a concomitant cross‐coupling between a gem ‐difluoroolefin and a non‐fluorinated olefin is reported. This highly efficient method provides facile access to both α‐CF 3 alkenes and β‐CF 3 ketones, which otherwise remain challenging to be directly prepared. The application of this method is further demonstrated by the synthesis of bioactive isoxazoline derivatives. This approach represents a conceptually novel route to trifluoromethylated compounds that combines the in situ generation of the CF 3 moiety and a CH functionalization in a single reaction system.