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A General Synthesis of Fluoroalkylated Alkenes by Palladium‐Catalyzed Heck‐Type Reaction of Fluoroalkyl Bromides
Author(s) -
Feng Zhang,
Min QiaoQiao,
Zhao HaiYang,
Gu JiWei,
Zhang Xingang
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409617
Subject(s) - palladium , chemistry , catalysis , heck reaction , halide , substrate (aquarium) , trifluoromethyl , organic chemistry , reaction conditions , combinatorial chemistry , oceanography , alkyl , geology
An efficient palladium‐catalyzed Heck‐type reaction of fluoroalkyl halides, including perfluoroalkyl bromides, trifluoromethyl iodides, and difluoroalkyl bromides, has been developed. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, and provides a general and straightforward access to fluoroalkylated alkenes which are of interest in life and material sciences.