Premium
A Systems Approach towards an Intelligent and Self‐Controlling Platform for Integrated Continuous Reaction Sequences
Author(s) -
Ingham Richard J.,
Battilocchio Claudio,
Fitzpatrick Daniel E.,
Sliwinski Eric,
Hawkins Joel M.,
Ley Steven V.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409356
Subject(s) - modular design , flow chemistry , computer science , process (computing) , continuous flow , operator (biology) , distributed computing , nanotechnology , process engineering , combinatorial chemistry , chemistry , biochemical engineering , engineering , materials science , programming language , biochemistry , repressor , transcription factor , gene
Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi‐step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi‐step flow sequences can be realized. These tools are applied to the synthesis of 2‐aminoadamantane‐2‐carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self‐regulation to be managed by a single operator.