Premium
Asymmetric Dual‐Reagent Catalysis: Mannich‐type Reactions Catalyzed by Ion Pair
Author(s) -
Wang HongYu,
Zhang Kai,
Zheng ChangWu,
Chai Zhuo,
Cao DongDong,
Zhang JiaXing,
Zhao Gang
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409342
Subject(s) - zwitterion , catalysis , chemistry , bifunctional , reactivity (psychology) , reagent , combinatorial chemistry , acrylate , mannich reaction , phosphine , substrate (aquarium) , organocatalysis , enantioselective synthesis , homogeneous catalysis , organic chemistry , molecule , polymer , alternative medicine , oceanography , monomer , pathology , geology , medicine
The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion‐pairing mode. This new catalytic system has been successfully applied to Mannich‐type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.