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Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug‐Resistant Pseudomonas aeruginosa
Author(s) -
Stach Michaela,
Siriwardena Thissa N.,
Köhler Thilo,
van Delden Christian,
Darbre Tamis,
Reymond JeanLouis
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409270
Subject(s) - pseudomonas aeruginosa , acinetobacter baumannii , multiple drug resistance , antimicrobial , dendrimer , peptide , microbiology and biotechnology , antimicrobial peptides , biology , computational biology , bacteria , chemistry , drug resistance , biochemistry , genetics
Multidrug‐resistant opportunistic bacteria, such as Pseudomonas aeruginosa , represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomimetic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug‐resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a systematic survey of the peptide sequences within the branches of a distinct type of third‐generation peptide dendrimers. Combined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug‐resistant bacterial pathogens.