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A Nanoparticle Catalyst for Heterogeneous Phase Para‐Hydrogen‐Induced Polarization in Water
Author(s) -
Glöggler Stefan,
Grunfeld Alexander M.,
Ertas Yavuz N.,
McCormick Jeffrey,
Wagner Shawn,
Schleker P. Philipp M.,
Bouchard LouisS.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409027
Subject(s) - polarization (electrochemistry) , chemistry , nanoparticle , spin isomers of hydrogen , polarizer , catalysis , hydrogen , radical , induced polarization , photochemistry , nuclear magnetic resonance , materials science , nanotechnology , optics , organic chemistry , birefringence , physics , electrical engineering , engineering , electrical resistivity and conductivity
Para‐hydrogen‐induced polarization (PHIP) is a technique capable of producing spin polarization at a magnitude far greater than state‐of‐the‐art magnets. A significant application of PHIP is to generate contrast agents for biomedical imaging. Clinically viable and effective contrast agents not only require high levels of polarization but heterogeneous catalysts that can be used in water to eliminate the toxicity impact. Herein, we demonstrate the use of Pt nanoparticles capped with glutathione to induce heterogeneous PHIP in water. The ligand‐inhibited surface diffusion on the nanoparticles resulted in a 1 H polarization of P =0.25 % for hydroxyethyl propionate, a known contrast agent for magnetic resonance angiography. Transferring the 1 H polarization to a 13 C nucleus using a para‐hydrogen polarizer yielded a polarization of 0.013 %. The nuclear‐spin polarizations achieved in these experiments are the first reported to date involving heterogeneous reactions in water.