Metal‐Free Radical  5‐exo‐ dig Cyclizations of Phenol‐Linked 1,6‐Enynes for the Synthesis of Carbonylated Benzofurans | Zendy

Hu Ming | Zendy; Song RenJie | Zendy; Li JinHeng | Zendy

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Metal‐Free Radical 5‐exo‐ dig Cyclizations of Phenol‐Linked 1,6‐Enynes for the Synthesis of Carbonylated Benzofurans

Author(s) -

Hu Ming,

Song RenJie,

Li JinHeng

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201408978

Subject(s) - chemistry , phenol , dig , bond cleavage , oxygen , cleavage (geology) , metal , radical , medicinal chemistry , oxygen atom , oxidative phosphorylation , stereochemistry , photochemistry , organic chemistry , catalysis , molecule , biochemistry , computer security , geotechnical engineering , fracture (geology) , computer science , engineering

A new metal‐free radical 5‐ exo ‐dig cyclization of phenol‐linked 1,6‐enynes with O 2 , 2,2,6,6‐tetramethyl‐1‐piperidinyloxy (TEMPO), and t BuONO is described. With this general method, carbonylated benzofurans can be accessed through incorporation of two oxygen atoms into the product from O 2 and TEMPO through dioxygen activation and oxidative cleavage of the NO bond, respectively.

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