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A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins
Author(s) -
Qu Bo,
Samankumara Lalith P.,
Ma Shengli,
Fandrick Keith R.,
Desrosiers JeanNicolas,
Rodriguez Sonia,
Li Zhibin,
Haddad Nizar,
Han Zhengxu S.,
McKellop Keith,
Pennino Scott,
Grinberg Nelu,
Gonnella Nina C.,
Song Jinhua J.,
Senanayake Chris H.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201408929
Subject(s) - iridium , oxazoline , chemistry , imine , asymmetric hydrogenation , catalysis , aryl , enantioselective synthesis , organic chemistry , polymer chemistry , alkyl
Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric hydrogenation of unfunctionalized 1‐aryl‐3,4‐dihydronaphthalenes under one atmosphere pressure of H 2 , up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1‐tetralones.