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An Allosteric Receptor by Simultaneous “Casting” and “Molding” in a Dynamic Combinatorial Library
Author(s) -
Li Jianwei,
Nowak Piotr,
Otto Sijbren
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201408907
Subject(s) - allosteric regulation , cooperativity , template , chemistry , cooperative binding , combinatorial chemistry , process (computing) , nanotechnology , computer science , materials science , receptor , binding site , biochemistry , operating system
Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian‐doll‐like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry.