Premium
Construction of Axial Chirality by Rhodium‐Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes
Author(s) -
Zheng Jun,
You ShuLi
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201408805
Subject(s) - axial chirality , rhodium , enantioselective synthesis , chemistry , catalysis , chirality (physics) , axial symmetry , combinatorial chemistry , heck reaction , organic chemistry , palladium , physics , chiral symmetry , quantum mechanics , quark , nambu–jona lasinio model
Enantioselective construction of axially chiral biaryls by direct CH bond functionalization reactions has been realized. Novel axially chiral biaryls were synthesized by the direct CH bond olefination of biaryl compounds, using a chiral [Cp*Rh III ] catalyst, in good to excellent yields and enantioselectivities. The obtained axially chiral biaryls were found as suitable ligands for rhodium‐catalyzed asymmetric conjugate additions.