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β‐Functionalization of Carboxylic Anhydrides with β‐Alkyl Substituents through Carbene Organocatalysis
Author(s) -
Jin Zhichao,
Chen Shaojin,
Wang Yuhuang,
Zheng Pengcheng,
Yang Song,
Chi Yonggui Robin
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201408604
Subject(s) - surface modification , electrophile , chemistry , carbene , nucleophile , alkyl , organocatalysis , catalysis , organic chemistry , carbon fibers , combinatorial chemistry , enantioselective synthesis , materials science , composite number , composite material
Abstract The first NHC‐catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β‐alkyl substituents work effectively.