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Bifunctional Submicron Colloidosomes Coassembled from Fluorescent and Superparamagnetic Nanoparticles
Author(s) -
Bollhorst Tobias,
Shahabi Shakiba,
Wörz Katharina,
Petters Charlotte,
Dringen Ralf,
Maas Michael,
Rezwan Kurosch
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201408515
Subject(s) - nanotechnology , nanoparticle , nanomedicine , materials science , iron oxide nanoparticles , superparamagnetism , magnetic nanoparticles , bifunctional , drug delivery , chemistry , magnetic field , organic chemistry , catalysis , physics , magnetization , quantum mechanics
Colloidosomes are microcapsules consisting of nanoparticle shells. These microcarriers can be self‐assembled from a wide range of colloidal particles with selective chemical, physical, and morphological properties and show promise for application in the field of theranostic nanomedicine. Previous studies have mainly focused on fairly large colloidosomes (>1 μm) based on a single kind of particle; however, the intrinsic building‐block nature of this microcarrier has not been exploited so far for the introduction of tailored functionality at the nanoscale. We report a synthetic route based on interfacial shear rheology studies that allows the simultaneous incorporation of different nanoparticles with distinct physical properties, that is, superparamagnetic iron oxide and fluorescent silica nanoparticles, in a single submicron colloidosome. These tailor‐made microcapsules can potentially be used in various biomedical applications, including magnetic hyperthermia, magnetic particle imaging, drug targeting, and bioimaging.