Premium
Sequential Synthesis of Coordination Polymersomes
Author(s) -
Ohtani Ryo,
Inukai Munehiro,
Hijikata Yuh,
Ogawa Tetsuya,
Takenaka Mikihito,
Ohba Masaaki,
Kitagawa Susumu
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201408101
Subject(s) - dabco , polymersome , chemistry , raft , liposome , lipid bilayer , octane , bilayer , membrane , vesicle , crystallography , polymer , polymer chemistry , copolymer , organic chemistry , amphiphile , biochemistry
Novel organic–inorganic hybrid liposomes, so‐called coordination polymersomes (CPsomes), with artificial domains that exhibit strong lateral cohesion were prepared by a three‐step procedure that formed a coordinative interaction leading to a lipid bilayer. First, the lipophilic complex (dabco‐C 18 )[Mn(N)(CN) 4 (dabco‐C 18 )] ( 1 ; dabco‐C 18 + =1,4‐diazabicyclo[2,2,2]octane‐(CH 2 ) 17 CH 3 cation), was synthesized. 1 has a lipophilic alkyl tail part and a tetracyanometallate head group, which can be used for an expansion to two‐dimensional coordination networks. Second, 1 and 1,2‐dipalmitoyl‐ sn ‐glycero‐3‐phosphocholine were mixed to prepare the liposomes. Finally, CPsomes were obtained by the addition of transition‐metal ions ( M ) to form unilamellar faceted liposomes with plain CP raft domains with MnCN M linkages. The concentration of 1 influences the size of the CP raft domains and the shape of the CPsomes. The synthesis of coordination polymers in lipid bilayers is a novel approach for the construction of artificial architectures as raft domains, for example, in cell membranes.