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Nickel‐Catalyzed Asymmetric Transfer Hydrogenation of Olefins for the Synthesis of α‐ and β‐Amino Acids
Author(s) -
Yang Peng,
Xu Haiyan,
Zhou Jianrong Steve
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201407744
Subject(s) - transfer hydrogenation , catalysis , rhodium , formic acid , chemistry , nickel , iridium , steric effects , ruthenium , noyori asymmetric hydrogenation , asymmetric hydrogenation , organic chemistry , metal , combinatorial chemistry , enantioselective synthesis
The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α‐ and β‐amino acid derivatives were obtained in good to excellent enantioselectivity. The key toward success was the use of the strongly donating and sterically demanding bisphosphine Binapine.