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Diketopyrrolopyrrole‐Porphyrin Conjugates with High Two‐Photon Absorption and Singlet Oxygen Generation for Two‐Photon Photodynamic Therapy
Author(s) -
Schmitt Julie,
Heitz Valérie,
Sour Angélique,
Bolze Frédéric,
Ftouni Hussein,
Nicoud JeanFrancois,
Flamigni Lucia,
Ventura Barbara
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201407537
Subject(s) - singlet oxygen , photodynamic therapy , phototoxicity , porphyrin , photochemistry , two photon excitation microscopy , absorption (acoustics) , two photon absorption , photosensitizer , materials science , singlet state , chemistry , oxygen , fluorescence , excited state , optics , laser , organic chemistry , physics , atomic physics , in vitro , composite material , biochemistry
Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and singlet‐oxygen generation. Reported here are two new diketopyrrolopyrrole‐porphyrin conjugates as robust two‐photon absorbing dyes with high two‐photon absorption cross‐sections within the therapeutic window. Furthermore, for the first time the singlet‐oxygen generation efficiency of diketopyrrolopyrrole‐containing systems is investigated. A preliminary study on cell culture showed efficient two‐photon induced phototoxicity.