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Switchable Amplification of Vibrational Circular Dichroism as a Probe of Local Chiral Structure
Author(s) -
Domingos Sérgio R.,
Sanders Hans J.,
Hartl František,
Buma Wybren J.,
Woutersen Sander
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201407376
Subject(s) - vibrational circular dichroism , circular dichroism , molecule , amplifier , chemistry , covalent bond , crystallography , molecular physics , materials science , optoelectronics , organic chemistry , cmos
A new method to detect the vibrational circular dichroism (VCD) of a localized part of a chiral molecular system is reported. A local VCD amplifier was implemented, and the distance dependence of the amplification was investigated in a series of peptides. The results indicate a characteristic distance of 2.0±0.3 bonds, which suggests that the amplification is a localized phenomenon. The amplifier can be covalently coupled to a specific part of a molecule, and can be switched ON and OFF electrochemically. By subtracting the VCD spectra obtained when the amplifier is in the ON and OFF states, the VCD of the local environment of the amplifier can be separated from the total VCD spectrum. Switchable local VCD amplification thus makes it possible to “zoom in” on a specific part of a chiral molecule.