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Photofunctional Nanomodulators for Bioexcitation
Author(s) -
Miyako Eijiro,
Russier Julie,
Mauro Matteo,
Cebrian Cristina,
Yawo Hiromu,
MénardMoyon Cécilia,
Hutchison James A.,
Yudasaka Masako,
Iijima Sumio,
De Cola Luisa,
Bianco Alberto
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201407169
Subject(s) - chemistry , organism , nanotechnology , laser , cell , biophysics , materials science , biochemistry , biology , optics , paleontology , physics
A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single‐cell level are required. In this study, we develop a new type of light‐driven nanomodulator comprising dye‐functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near‐infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single‐cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single‐cell analyses and innovative cell therapies.