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Polydimethylsiloxane: A General Matrix for High‐Performance Chromatographic NMR Spectroscopy
Author(s) -
Huang Shaohua,
Gao Jun,
Wu Rui,
Li Shengying,
Bai Zhengwu
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406967
Subject(s) - characterization (materials science) , polydimethylsiloxane , nuclear magnetic resonance spectroscopy , spectroscopy , matrix (chemical analysis) , chemistry , materials science , chromatography , nanotechnology , organic chemistry , physics , quantum mechanics
Abstract The detection and structural characterization of the components of a mixture is a challenging task. Therefore, the development of a facile and general method that enables both the separation and the structural characterization of the components is desired. Diffusion‐ordered NMR spectroscopy (DOSY) with the aid of a matrix is a promising tool for this purpose. However, because the currently existing matrices only separate limited components, the application of the DOSY technique is restricted. Herein we introduce a new versatile matrix, poly(dimethylsiloxane), which can fully separate many mixtures of different structural types by liquid‐state NMR spectroscopy. With poly(dimethylsiloxane), liquid‐state chromatographic NMR spectroscopy could become a general approach for the structural elucidation of mixtures of compounds.