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Synthesis of α‐Aryl Esters and Nitriles: Deaminative Coupling of α‐Aminoesters and α‐Aminoacetonitriles with Arylboronic Acids
Author(s) -
Wu Guojiao,
Deng Yifan,
Wu Chaoqiang,
Zhang Yan,
Wang Jianbo
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406765
Subject(s) - chemistry , aryl , functional group , reaction conditions , transition metal , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , polymer , alkyl
Transition‐metal‐free synthesis of α‐aryl esters and nitriles using arylboronic acids with α‐aminoesters and α‐aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp 3 )N bonds into C(sp 3 )C(sp 2 ) bonds. The reaction conditions are mild, demonstrate good functional‐group tolerance, and can be scaled up.