Sustainable Three‐Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines | Zendy

Mampuys Pieter | Zendy; Zhu Yanping | Zendy; Vlaar Tjøstil | Zendy; Ruijter Eelco | Zendy; Orru Romano V. A. | Zendy; Maes Bert U. W. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Sustainable Three‐Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines

Author(s) -

Mampuys Pieter,

Zhu Yanping,

Vlaar Tjøstil,

Ruijter Eelco,

Orru Romano V. A.,

Maes Bert U. W.

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201406717

Subject(s) - chemistry , aryl , formal synthesis , alkyl , component (thermodynamics) , combinatorial chemistry , organic chemistry , physics , thermodynamics

Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards S ‐alkyl and S ‐aryl isothioureas through a copper(I)‐catalyzed three‐component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research