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Dehydrogenative N‐Incorporation: A Direct Approach to Quinoxaline N ‐Oxides under Mild Conditions
Author(s) -
Chen Feng,
Huang Xiaoqiang,
Li Xinyao,
Shen Tao,
Zou Miancheng,
Jiao Ning
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406479
Subject(s) - quinoxaline , chemistry , bond cleavage , surface modification , nitrite , combinatorial chemistry , cleavage (geology) , medicinal chemistry , organic chemistry , catalysis , materials science , nitrate , fracture (geology) , composite material
An efficient method for the synthesis of quinoxaline N ‐oxides proceeds by the dehydrogenative N‐incorporation of simple imines by C(sp 2 )H and C(sp 3 )H bond functionalization. The overall transformation involves the cleavage of three CH bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily available tert ‐butyl nitrite (TBN) was employed as the NO source.