Premium
Gold(I) Catalysis at Extreme Concentrations Inside Self‐Assembled Nanospheres
Author(s) -
GramageDoria Rafael,
Hessels Joeri,
Leenders Stefan H. A. M.,
Tröppner Oliver,
Dürr Maximilian,
IvanovićBurmazović Ivana,
Reek Joost N. H.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406415
Subject(s) - catalysis , substrate (aquarium) , intramolecular force , chemistry , selectivity , transition metal , homogeneous catalysis , solubility , chemical engineering , homogeneous , heterogeneous catalysis , nanotechnology , inorganic chemistry , materials science , organic chemistry , oceanography , physics , engineering , thermodynamics , geology
Homogeneous transition‐metal catalysis is a crucial technology for the sustainable preparation of valuable chemicals. The catalyst concentration is usually kept as low as possible, typically at m M or μ M levels, and the effect of high catalyst concentration is hardly exploited because of solubility issues and the inherent unfavorable catalyst/substrate ratio. Herein, a self‐assembly strategy is reported which leads to local catalyst concentrations ranging from 0.05 M to 1.1 M , inside well‐defined nanospheres, whilst the overall catalyst concentration in solution remains at the conventional m M levels. We disclose that only at this high concentration, the gold(I) chloride is reactive and shows high selectivity in intramolecular CO and CC bond‐forming cyclization reactions.