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High Performance of a Palladium Phosphinooxazoline Catalyst in the Asymmetric Arylation of Cyclic N ‐Sulfonyl Ketimines
Author(s) -
Jiang Chunhui,
Lu Yixin,
Hayashi Tamio
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406147
Subject(s) - stereocenter , sulfonyl , palladium , oxazoline , chemistry , catalysis , cationic polymerization , enantioselective synthesis , phosphine , ligand (biochemistry) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl , biochemistry , receptor
A cationic palladium complex with a chiral phosphine‐oxazoline ligand ( i Pr‐phox) showed high catalytic activity and enantioselectivity in the asymmetric addition of arylboronic acids to six‐membered cyclic N‐sulfonyl ketimines to give high yields of the corresponding chiral cyclic sulfamidates with 96–99.9 % ee . The products have tetrasubstituted stereogenic centers with an amino group and a triaryl or alkyldiaryl group as substituents.