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CH Functionalization/Asymmetric Michael Addition Cascade Enabled by Relay Catalysis: Metal Carbenoid Used for CC Bond Formation
Author(s) -
Chen DianFeng,
Zhao Feng,
Hu Yue,
Gong LiuZhu
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406098
Subject(s) - carbenoid , chemistry , michael reaction , rhodium , surface modification , ruthenium , indole test , catalysis , combinatorial chemistry , squaramide , enantioselective synthesis , stereochemistry , organic chemistry , organocatalysis
A combination of either ruthenium(II) or rhodium(II) complexes and quinine‐derived squaramide enables 3‐diazooxindoles, indoles, and nitroalkenes to undergo highly efficient asymmetric three‐component reactions, thus affording optically active 3,3′‐bis(indole)s through a consecutive CC bond‐forming sequence, which turned out to be applicable to the facile total synthesis of (−)‐folicanthine.