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Iridium‐Catalyzed Enantioselective Allyl–Allylsilane Cross‐Coupling
Author(s) -
Hamilton James Y.,
Hauser Nicole,
Sarlah David,
Carreira Erick M.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201406077
Subject(s) - enantioselective synthesis , phosphoramidite , allylic rearrangement , iridium , chemistry , olefin fiber , catalysis , organic chemistry , combinatorial chemistry , dna , biochemistry , oligonucleotide
An enantioselective allyl–allylsilane cross‐coupling involving racemic branched allylic alcohols and allylsilanes is reported. An iridium‐(P,olefin) phosphoramidite complex enables the transformation with high regio‐ and stereoselectivity under operationally simple conditions. The utility of the coupling is demonstrated in a concise catalytic, enantioselective synthesis of a pyrethroid insecticide protrifenbute.