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Exceedingly Fast Copper(II)‐Promoted ortho CH Trifluoromethylation of Arenes using TMSCF 3
Author(s) -
Shang Ming,
Sun ShangZheng,
Wang HongLi,
Laforteza Brian N.,
Dai HuiXiong,
Yu JinQuan
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404822
Subject(s) - trifluoromethylation , chemistry , electrophile , copper , electrophilic aromatic substitution , medicinal chemistry , electrophilic substitution , combinatorial chemistry , organic chemistry , catalysis , trifluoromethyl , alkyl
The direct ortho ‐trifluoromethylation of arenes, including heteroarenes, with TMSCF 3 has been accomplished by a copper(II)‐promoted CH activation reaction which completes within 30 minutes. Mechanistic investigations are consistent with the involvement of CH activation, rather than a simple electrophilic aromatic substitution (S E Ar), as the key step.
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