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Synthesis of Isocoumarins through Three‐Component Couplings of Arynes, Terminal Alkynes, and Carbon Dioxide Catalyzed by an NHC–Copper Complex
Author(s) -
Yoo WooJin,
Nguyen Thanh V. Q.,
Kobayashi Shū
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404692
Subject(s) - isocoumarins , aryne , copper , carbene , catalysis , chemistry , component (thermodynamics) , carbon dioxide , coupling reaction , terminal (telecommunication) , combinatorial chemistry , organic chemistry , computer science , physics , telecommunications , thermodynamics
A copper‐catalyzed multicomponent coupling reaction between in situ generated ortho ‐arynes, terminal alkynes, and carbon dioxide was developed to access isocoumarins in moderate to good yields. The key to this CO 2 ‐incorporating reaction was the use of a versatile N‐heterocyclic carbene/copper complex that was able to catalyze multiple transformations within the three‐component reaction.