Premium
Cobalt‐Catalyzed, Aminoquinoline‐Directed C(sp 2 )H Bond Alkenylation by Alkynes
Author(s) -
Grigorjeva Liene,
Daugulis Olafs
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404579
Subject(s) - catalysis , cobalt , chemistry , medicinal chemistry , triple bond , polymer chemistry , combinatorial chemistry , organic chemistry , double bond
A method for cobalt‐catalyzed, aminoquinoline‐ and picolinamide‐directed C(sp 2 )H bond alkenylation by alkynes was developed. The method shows excellent functional‐group tolerance and both internal and terminal alkynes are competent substrates for the coupling. The reaction employs a Co(OAc) 2 ⋅4 H 2 O catalyst, Mn(OAc) 2 co‐catalyst, and oxygen (from air) as a terminal oxidant.