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Enzymetically Regulating the Self‐Healing of Protein Hydrogels with High Healing Efficiency
Author(s) -
Gao Yuzhou,
Luo Quan,
Qiao Shanpeng,
Wang Liang,
Dong Zeyuan,
Xu Jiayun,
Liu Junqiu
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404531
Subject(s) - self healing hydrogels , glucose oxidase , glutaraldehyde , covalent bond , self healing , chemistry , wound healing , bovine serum albumin , catalase , surface modification , biophysics , enzyme , biochemistry , polymer chemistry , organic chemistry , surgery , medicine , alternative medicine , pathology , biology
Enzyme‐mediated self‐healing of dynamic covalent bond‐driven protein hydrogels was realized by the synergy of two enzymes, glucose oxidase (GOX) and catalase (CAT). The reversible covalent attachment of glutaraldehyde to lysine residues of GOX, CAT, and bovine serum albumin (BSA) led to the formation and functionalization of the self‐healing protein hydrogel system. The enzyme‐mediated protein hydrogels exhibit excellent self‐healing properties with 100 % recovery. The self‐healing process was reversible and effective with an external glucose stimulus at room temperature.