Broad‐Spectrum Catalysts for the Ambient Temperature Anti‐Markovnikov Hydration of Alkynes | Zendy

Li Le | Zendy; Zeng Mingshuo | Zendy; Herzon Seth B. | Zendy

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Broad‐Spectrum Catalysts for the Ambient Temperature Anti‐Markovnikov Hydration of Alkynes

Author(s) -

Li Le,

Zeng Mingshuo,

Herzon Seth B.

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201404320

Subject(s) - markovnikov's rule , catalysis , alkyne , ruthenium , chemistry , yield (engineering) , trifluoromethyl , metal , bipyridine , combinatorial chemistry , broad spectrum , organic chemistry , materials science , regioselectivity , metallurgy , alkyl , crystal structure

Anti‐Markovnikov alkyne hydration provides a valuable route to aldehydes. Half‐sandwich ruthenium complexes ligated by 5,5′‐bis(trifluoromethyl)‐2,2′‐bipyridine are remarkably active for this transformation. In the presence of 2 mol % metal, a wide range of functionalized aliphatic and aromatic alkynes are hydrated in high yield at ambient temperature.

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