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Broad‐Spectrum Catalysts for the Ambient Temperature Anti‐Markovnikov Hydration of Alkynes
Author(s) -
Li Le,
Zeng Mingshuo,
Herzon Seth B.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404320
Subject(s) - markovnikov's rule , catalysis , alkyne , ruthenium , chemistry , yield (engineering) , trifluoromethyl , metal , bipyridine , combinatorial chemistry , broad spectrum , organic chemistry , materials science , regioselectivity , metallurgy , alkyl , crystal structure
Anti‐Markovnikov alkyne hydration provides a valuable route to aldehydes. Half‐sandwich ruthenium complexes ligated by 5,5′‐bis(trifluoromethyl)‐2,2′‐bipyridine are remarkably active for this transformation. In the presence of 2 mol % metal, a wide range of functionalized aliphatic and aromatic alkynes are hydrated in high yield at ambient temperature.