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Hexacoordinate Nickel(II)/(III) Complexes that Mimic the Catalytic Cycle of Nickel Superoxide Dismutase
Author(s) -
Chatterjee Sudip K.,
Maji Ram Chandra,
Barman Suman Kumar,
Olmstead Marilyn M.,
Patra Apurba K.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404133
Subject(s) - hexacoordinate , nickel , chemistry , catalytic cycle , electron transfer , ligand (biochemistry) , catalysis , superoxide dismutase , octahedron , stereochemistry , enzyme , crystallography , photochemistry , biochemistry , crystal structure , receptor , organic chemistry , silicon
A functional model complex of nickel superoxide dismutase (NiSOD) with a non‐peptide ligand which mimics the full catalytic cycle of NiSOD is unknown. Similarly, it has not been fully elucidated whether NiSOD activity is a result of an outer‐ or inner‐sphere electron‐transfer mechanism. With this in mind, two octahedral nickel(II)/(III) complexes of a bis‐tridentate N 2 S donor carboxamide ligand, N ‐2‐phenylthiophenyl‐2′‐pyridinecarboxamide (HL Ph ), have been synthesized, structurally characterized, and their SOD activities examined. These complexes mimic the full catalytic cycle of NiSOD. Electrochemical experiments support an outer‐sphere electron‐transfer mechanism for their SOD activity.