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Development of CN Coupling Using Mechanochemistry: Catalytic Coupling of Arylsulfonamides and Carbodiimides
Author(s) -
Tan Davin,
Mottillo Cristina,
Katsenis Athanassios D.,
Štrukil Vjekoslav,
Friščić Tomislav
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404120
Subject(s) - mechanochemistry , chemistry , coupling (piping) , catalysis , molecule , combinatorial chemistry , sulfonyl , organic chemistry , computational chemistry , materials science , alkyl , metallurgy
Reported herein is the mechanochemical synthesis of sulfonyl guanidines, a family of molecules which are relevant as pharmaceuticals and herbicides, by direct coupling of sulfonamides and aromatic or aliphatic carbodiimides. Attempts to conduct the coupling in solution have either failed or given very low conversions, thus demonstrating mechanochemistry as the necessary component for the discovery of this synthetic strategy.