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Highly Diastereodivergent Synthesis of Tetrasubstituted Cyclohexanes Catalyzed by Modularly Designed Organocatalysts
Author(s) -
Rairmal K.,
Huang Huicai,
Zhao John C.G.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201404072
Subject(s) - cyclohexanes , cinchona , chemistry , enantioselective synthesis , stereoselectivity , tandem , cascade reaction , organocatalysis , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , materials science , composite material
A highly diastereodivergent synthesis of tetrasubstituted cyclohexanes has been achieved using modularly designed organocatalysts (MDOs) which are self‐assembled in situ from amino acids and cinchona alkaloid derivatives. Diastereodivergence is realized through controlling the stereoselectivity of the individual steps of a tandem Michael/Michael reaction. Up to 8 of the 16 possible stereoisomers have been successfully obtained in high stereoselectivities using MDOs for the tandem reaction and an ensuing epimerization. The method was used in the enantioselective synthesis of the natural products (−)‐α‐ and β‐lycoranes.