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N ‐Trifluoromethylthiosaccharin: An Easily Accessible, Shelf‐Stable, Broadly Applicable Trifluoromethylthiolating Reagent
Author(s) -
Xu Chunfa,
Ma Bingqing,
Shen Qilong
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403983
Subject(s) - reagent , nucleophile , electrophile , chemistry , combinatorial chemistry , organic chemistry , off the shelf , catalysis , computer science , software engineering
A new, electrophilic trifluoromethylthiolating reagent, N ‐trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N ‐trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron‐rich arenes, aldehydes, ketones, acyclic β‐ketoesters, and alkynes under mild reaction conditions.