N ‐Trifluoromethylthiosaccharin: An Easily Accessible, Shelf‐Stable, Broadly Applicable Trifluoromethylthiolating Reagent | Zendy

Xu Chunfa | Zendy; Ma Bingqing | Zendy; Shen Qilong | Zendy

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N ‐Trifluoromethylthiosaccharin: An Easily Accessible, Shelf‐Stable, Broadly Applicable Trifluoromethylthiolating Reagent

Author(s) -

Xu Chunfa,

Ma Bingqing,

Shen Qilong

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201403983

Subject(s) - reagent , nucleophile , electrophile , chemistry , combinatorial chemistry , organic chemistry , off the shelf , catalysis , computer science , software engineering

A new, electrophilic trifluoromethylthiolating reagent, N ‐trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N ‐trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron‐rich arenes, aldehydes, ketones, acyclic β‐ketoesters, and alkynes under mild reaction conditions.

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