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Ligand‐Enabled Triple CH Activation Reactions: One‐Pot Synthesis of Diverse 4‐Aryl‐2‐quinolinones from Propionamides
Author(s) -
Deng Youqian,
Gong Wei,
He Jian,
Yu JinQuan
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403878
Subject(s) - chemistry , aryl , stereospecificity , ligand (biochemistry) , combinatorial chemistry , triple bond , stereochemistry , medicinal chemistry , catalysis , organic chemistry , double bond , receptor , alkyl , biochemistry
Diverse 4‐aryl‐2‐quinolinones are prepared from propionamides in one pot by ligand‐promoted triple sequential CH activation reactions and a stereospecific Heck reaction. In these cascade reactions, three new CC bonds and one CN bond are formed to rapidly build molecular complexity from propionic acid.