Nickel‐Catalyzed α‐Arylation of Ketones with Phenol Derivatives | Zendy

Takise Ryosuke | Zendy; Muto Kei | Zendy; Yamaguchi Junichiro | Zendy; Itami Kenichiro | Zendy

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Nickel‐Catalyzed α‐Arylation of Ketones with Phenol Derivatives

Author(s) -

Takise Ryosuke,

Muto Kei,

Yamaguchi Junichiro,

Itami Kenichiro

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201403823

Subject(s) - phenol , chemistry , catalysis , thiophene , nickel , ligand (biochemistry) , transformation (genetics) , combinatorial chemistry , crystal structure , organic chemistry , biochemistry , receptor , gene

The nickel‐catalyzed α‐arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α‐arylketones. For this transformation, 3,4‐bis(dicyclohexylphosphino)thiophene (dcypt) was identified as a new, enabling, air‐stable ligand for this transformation. The intermediate of an assumed CO oxidative addition was isolated and characterized by X‐ray crystal‐structure analysis.

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