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Nickel‐Catalyzed α‐Arylation of Ketones with Phenol Derivatives
Author(s) -
Takise Ryosuke,
Muto Kei,
Yamaguchi Junichiro,
Itami Kenichiro
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403823
Subject(s) - phenol , chemistry , catalysis , thiophene , nickel , ligand (biochemistry) , transformation (genetics) , combinatorial chemistry , crystal structure , organic chemistry , biochemistry , receptor , gene
The nickel‐catalyzed α‐arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α‐arylketones. For this transformation, 3,4‐bis(dicyclohexylphosphino)thiophene (dcypt) was identified as a new, enabling, air‐stable ligand for this transformation. The intermediate of an assumed CO oxidative addition was isolated and characterized by X‐ray crystal‐structure analysis.