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Ruthenium‐Catalyzed Reductive Methylation of Imines Using Carbon Dioxide and Molecular Hydrogen
Author(s) -
Beydoun Kassem,
Ghattas Ghazi,
Thenert Katharina,
Klankermayer Jürgen,
Leitner Walter
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403711
Subject(s) - chemistry , ruthenium , catalysis , reducing agent , methylation , combinatorial chemistry , triphos , hydrogen molecule , hydrogen , organic chemistry , biochemistry , gene
The use of the well‐defined [Ru(triphos)(tmm)] catalyst, CO 2 as C 1 source, and H 2 as reducing agent enabled the reductive methylation of isolated imines, as well as the direct coupling of amines with aldehydes and the subsequent reductive methylation of the in situ formed imines. The method, which afforded the corresponding N‐methyl amines in very good to excellent yields, was also used for the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis.