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Palladium‐Catalyzed Cascade Annulation To Construct Functionalized β‐ and γ‐Lactones in Ionic Liquids
Author(s) -
Li Jianxiao,
Yang Wanfei,
Yang Shaorong,
Huang Liangbin,
Wu Wanqing,
Sun Yadong,
Jiang Huanfeng
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403341
Subject(s) - annulation , ionic liquid , palladium , catalysis , cascade , chemistry , ionic bonding , combinatorial chemistry , cascade reaction , reaction conditions , organic chemistry , ion , chromatography
A highly efficient and mild palladium‐catalyzed, one‐pot, four‐step cascade annulation has been developed to afford functionalized β‐ and γ‐lactones in moderate to good yields with high regio‐ and diastereoselectivities in ionic liquids. The employment of ionic liquids under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active β‐ and γ‐lactones.