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Iridium‐Catalyzed Arylative Cyclization of Alkynones by 1,4‐Iridium Migration
Author(s) -
Partridge Benjamin M.,
Solana González Jorge,
Lam Hon Wai
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403271
Subject(s) - iridium , rhodium , chemistry , catalysis , combinatorial chemistry , palladium , organic chemistry
1,4‐Metal migrations enable the remote functionalization of CH bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4‐migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the iridium‐catalyzed arylative cyclization of alkynones with arylboronic acids is described. To our knowledge, these reactions involve the first reported examples of 1,4‐iridium migration.