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Control of Three‐Dimensional Cell Adhesion by the Chirality of Nanofibers in Hydrogels
Author(s) -
Liu GuoFeng,
Zhang Di,
Feng ChuanLiang
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403249
Subject(s) - nanofiber , chirality (physics) , extracellular matrix , adhesion , cell adhesion , self healing hydrogels , fibronectin , biophysics , nanotechnology , extracellular , materials science , chemistry , polymer chemistry , biochemistry , composite material , chiral symmetry , biology , physics , quantum mechanics , nambu–jona lasinio model , quark
Abstract In the three‐dimensional (3D) extracellular matrix (ECM), the influence of nanofiber chirality on cell behavior is very important; the helical nanofibrous structure is closely related to the relevant biological events. Herein, we describe the use of the two enantiomers of a 1,4‐benzenedicarboxamide phenylalanine derivative as supramolecular gelators to investigate the influence of the chirality of nanofibers on cell adhesion and proliferation in three dimensions. It was found that left‐handed helical nanofibers can increase cell adhesion and proliferation, whereas right‐handed nanofibers have the opposite effect. These effects are ascribed to the mediation of the stereospecific interaction between chiral nanofibers and fibronectin. The results stress the crucial role of the chirality of nanofibers on cell‐adhesion and cell‐proliferation behavior in 3D environments.