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Mimicking Biological Membranes with Programmable Glycan Ligands Self‐Assembled from Amphiphilic Janus Glycodendrimers
Author(s) -
Zhang Shaodong,
Moussodia RalphOlivier,
Sun HaoJan,
Leowanawat Pawaret,
Muncan Adam,
Nusbaum Christopher D.,
Chelling Kathleen M.,
Heiney Paul A.,
Klein Michael L.,
André Sabine,
Roy René,
Gabius HansJ.,
Percec Virgil
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201403186
Subject(s) - janus , amphiphile , vesicle , chemistry , drug delivery , nanotechnology , combinatorial chemistry , membrane , nanomedicine , organic chemistry , nanoparticle , materials science , biochemistry , copolymer , polymer
An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self‐assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.