Premium
Rhodium(II)‐Catalyzed Intramolecular Cycloisomerizations of Methylenecyclopropanes with N ‐Sulfonyl 1,2,3‐Triazoles
Author(s) -
Chen Kai,
Zhu ZiZhong,
Zhang YongSheng,
Tang XiangYing,
Shi Min
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402803
Subject(s) - rhodium , cycloisomerization , chemistry , intramolecular force , carbene , sulfonyl , catalysis , combinatorial chemistry , tandem , stereochemistry , medicinal chemistry , organic chemistry , alkyl , materials science , composite material
A novel rhodium(II)‐catalyzed tandem cycloisomerization of methylenecyclopropanes (MCPs) with N ‐sulfonyl 1,2,3‐triazoles is disclosed. The reaction produces a series of highly functionalized polycyclic N heterocycles via a rhodium imino carbene intermediate. A distinct feature of this divergent synthesis is that different types of substrates control the reaction pathways. Moreover, several interesting transformations of these products to construct diazabicyclo[3.2.1]octane derivatives are also reported.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom