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Visual Displays that Directly Interface and Provide Read‐Outs of Molecular States via Molecular Graphics Processing Units
Author(s) -
Poje Julia E.,
Kastratovic Tamara,
Macdonald Andrew R.,
Guillermo Ana C.,
Troetti Steven E.,
Jabado Omar J.,
Fanning M. Leigh,
Stefanovic Darko,
Macdonald Joanne
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402698
Subject(s) - molecular graphics , graphics , computer science , molecular machine , molecular electronics , nanotechnology , molecular switch , computer graphics , computer graphics (images) , chemistry , molecule , materials science , organic chemistry
The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic‐decipherable signals. We demonstrate a new method for obtaining read‐outs of molecular states that uses graphics processing units made from molecular circuits. Because they are made from molecules, the units are able to directly interact with molecular systems. We developed deoxyribozyme‐based graphics processing units able to monitor nucleic acids and output alphanumerical read‐outs via a fluorescent display. Using this design we created a molecular 7‐segment display, a molecular calculator able to add and multiply small numbers, and a molecular automaton able to diagnose Ebola and Marburg virus sequences. These molecular graphics processing units provide insight for the construction of autonomous biosensing devices, and are essential components for the development of molecular computing platforms devoid of electronics.