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Copper‐Catalyzed Regioselective ortho CH Cyanation of Vinylarenes
Author(s) -
Yang Yang,
Buchwald Stephen L.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402449
Subject(s) - cyanation , regioselectivity , chemistry , copper , catalysis , surface modification , combinatorial chemistry , organic chemistry
A copper‐based catalytic technique for the regioselective ortho CH cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper‐catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction.