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Synthesis, Discovery, and Quantitation of Dihomo‐Isofurans: Biomarkers for In Vivo Adrenic Acid Peroxidation
Author(s) -
de La Torre Aurélien,
Lee Yiu Yiu,
Oger Camille,
Sangild Per Torp,
Durand Thierry,
Lee Jetty ChungYung,
Galano JeanMarie
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402440
Subject(s) - polyunsaturated fatty acid , lipid peroxidation , chemistry , biochemistry , lipidomics , in vivo , biomarker , enzyme , fatty acid , biology , microbiology and biotechnology
The growing importance of lipidomics, and the interest of non‐enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo‐IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC‐MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.