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Complex Reconfiguration of DNA Nanostructures
Author(s) -
Wei Bryan,
Ong Luvena L.,
Chen Jeffrey,
Jaffe Alexander S.,
Yin Peng
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402437
Subject(s) - control reconfiguration , dna nanotechnology , dna origami , component (thermodynamics) , tile , dna , nanotechnology , computer science , topology (electrical circuits) , materials science , biological system , nanostructure , chemistry , physics , engineering , biology , embedded system , biochemistry , electrical engineering , composite material , thermodynamics
Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold‐mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which a structure changes from a starting shape to another arbitrarily prescribed shape. To address this challenge, we have developed a general structural‐reconfiguration method that utilizes the modularly interconnected architecture of single‐stranded DNA tile and brick structures. The removal of one component strand reveals a newly exposed toehold on a neighboring strand, thus enabling us to remove regions of connected component strands without the need to modify the strands with predesigned external toeholds. By using this method, we reconfigured a two‐dimensional rectangular DNA canvas into diverse prescribed shapes. We also used this method to reconfigure a three‐dimensional DNA cuboid.