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Chemical‐Shift‐Resolved 19 F NMR Spectroscopy between 13.5 and 135 MHz: Overhauser–DNP‐Enhanced Diagonal Suppressed Correlation Spectroscopy
Author(s) -
George Christy,
Chandrakumar Narayanan
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402320
Subject(s) - homonuclear molecule , spectroscopy , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , transverse relaxation optimized spectroscopy , chemistry , analytical chemistry (journal) , diagonal , nuclear overhauser effect , nuclear magnetic resonance , molecule , fluorine 19 nmr , physics , stereochemistry , organic chemistry , mathematics , geometry , quantum mechanics
Overhauser–DNP‐enhanced homonuclear 2D 19 F correlation spectroscopy with diagonal suppression is presented for small molecules in the solution state at moderate fields. Multi‐frequency, multi‐radical studies demonstrate that these relatively low‐field experiments may be operated with sensitivity rivalling that of standard 200–1000 MHz NMR spectroscopy. Structural information is accessible without a sensitivity penalty, and diagonal suppressed 2D NMR correlations emerge despite the general lack of multiplet resolution in the 1D ODNP spectra. This powerful general approach avoids the rather stiff excitation, detection, and other special requirements of high‐field 19 F NMR spectroscopy.